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Author

Chun-Nan Yeh

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Open access Aug 2026

Membrane and soluble VTCN1 (B7H4) converge on Src signaling to mediate gemcitabine resistance in intrahepatic cholangiocarcinoma

Rationale A combination of gemcitabine (GEM)-based chemotherapy and an immune checkpoint inhibitor is the standard treatment for patients with advanced intrahepatic cholangiocarcinoma (iCCA). However, 70% of patients develop progressive disease following GEM treatment, highlighting the urgent need for therapeutic strat...

Yi-Ru Pan, Sheng-Hsuan Lin, Yu-Chan Chang et al. · 0 citations
Open access Jul 2026

Targeting the KRAS G12D mutant suppresses tumor growth in a syngeneic mouse cholangiocarcinoma model through activation of immune cells 2258895

The in vitro proliferation of AKP-M4 cells, but not KRAS wild-type SNU-1079 and SSP-25 cells, was reduced by the KRAS G12D mutation inhibitor MRTX-1133, which supports the development of KRAS mutation inhibitor for CCA treatment.

J. Hung, Tsai-Hsien Hung, Chun-Nan Yeh et al. · 0 citations

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