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Author

Chun-He Guo

2 papers indexed here

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Open access Sep 2026

CRISPR and yeast two-hybrid screens identify CD81 as a proviral host factor for PRRSV

ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major economic burden on the global swine industry. Identifying host factors that mediate viral invasion is critical for developing antiviral strategies. Here, using a CRISPR screen targeting genes encoding cell surface CD proteins combined...

Yong-Jie Chen, Zhan He, Yan-Fei Pan et al. · 0 citations
Open access Sep 2026

The E3 ubiquitin ligase IDOL suppresses PRRSV replication by targeting viral Nsp3 for SQSTM1-mediated selective autophagic degradation

An autophagy-dependent antiviral mechanism is uncovered, IDOL is established as an innate immune regulator with a non-canonical function, and a viral immune evasion strategy is defined, positioning IDOL as a promising therapeutic target for PRRSV control.

Jie-Cong Yan, Yu-Han Wu, Hui Xu et al. · 0 citations

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