Author

Chun-Gui Xu

2 papers indexed here

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Open access Oct 2026

Demoted CD4+ T-cell activity resulted from CTNNB1 mutations resists lenvatinib plus anti-PD1 in HCC

Hepatocellular carcinoma (HCC) patients frequently fail to respond to combined anti-PD1 immunotherapy, though pre-existing neoantigen-specific CD8⁺ T cells within tumor microenvironment are reinvigorated upon PD1 blockaded. Tumor-intrinsic mechanisms driving the therapeutic resistance in HCC remain unclear. Here, w...

Fei Zhao, Kun Chen, Yi-Qiao Deng et al. · Cell Death & Disease · 0 citations

Sep 2026

A KRAS-ERK-associated model for molecular stratification and prognosis prediction: Highlighting the tumorigenic role of ARNTL2 in KRAS-mutant pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by poor survival rates and limited therapeutic options. Oncogenic KRAS mutations are frequent in pancreatic cancer patients and are key drivers of tumorigenesis. Recent studies have underscored the essential role of extra...

Weihao Lin, Chun-Gui Xu, Chao-Qun Liu et al. · Biochemical and Biophysical... · 0 citations