Chun-Chao Feng

Structural Basis of a High-Affinity Antibody Binding to Glycoprotein with Glycocalyx Decay

Cancer-associated defects in mucin-type O-glycosylation expose truncated glycans on cell-surface glycoproteins and create tumor-associated glycopeptide epitopes. However, the structural principles by which antibodies recognize specific MUC1 glycopeptide sequences remain incompletely defined. Here, we report the molecul...