Chuan Zhang

Nanomicelles self-assembled using cyclosporine A-hyaluronic acid conjugates for dry eye disease treatment.

Dry eye disease is a chronic inflammatory disorder of the ocular surface in which tear film instability and hyperosmolarity perpetuate a self-sustaining cycle of epithelial damage and inflammation; however, the therapeutic efficacy of topical cyclosporine A (CsA), a mainstay of treatment, is severely limited by rapid t...