Sep 2026
MMSDH facilitates ACSL4 propionylation to counteract ferroptosis upon hypoxia and impairs PDAC chemotherapy efficacy.
Pei-Xiang Zheng, Yan-Ni Lin, Mei-Yin Zhang et al.
· Nature Cancer · 0 citations
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Sep 2026
A Metabolic Nanoplatform Potentiates Triple-Negative Breast Cancer Radiosensitivity via Disrupting Carbonic Anhydrase IX/Pentose Phosphate Pathway Crosstalk
Radiotherapy resistance in tumors driven by metabolic adaptations within acidic microenvironments involves the upregulation of both carbonic anhydrase IX (CA IX) and the pentose phosphate pathway (PPP) as well as the functional crosstalk between them. To overcome this, we developed a polyvinylpyrrolidone (PVP)-modifi...
Zhi-Li Ma, Bin Zhao, Yun Wang et al.
· ACS Nano · 0 citations