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Chuan He

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Open access Sep 2026

A One-Step Chemoselective Strategy for Hydroxymethylcytosine Sequencing in DNA and RNA

5-Hydroxymethylcytosine (5hmC) is a relatively stable chemical mark formed by oxidation of 5-methylcytosine in DNA, while its RNA counterparts, 5-hydroxymethylcytidine (hm5C) and 2”-O-methyl-5-hydroxymethylcytidine (hm5Cm), have recently emerged as potential regulators of post-transcriptional processes. Existing 5hmC e...

Jia-Hao Li, Pei-Hong Zhang, Yanchu Arvin Wang et al. · 0 citations
Open access Aug 2026

Expansion of functional human long-term HSCs through restraining excessive cell cycle activation.

A niche-mimetic culture system that integrates intrinsic and extrinsic bone marrow regulatory cues, including pharmacologic inhibition of the m6A reader YTHDF2 using the small molecule Y13-27, a three-dimensional microenvironment, and N-cadherin-mediated adhesion is established that preserves transcriptional and epigen...

Xinjian Mao, Ning Zhang, Xi C. He et al. · 0 citations

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