Open access
Sep 2026
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
ABSTRACT TP53 inactivation is a key event in osteosarcoma (OS) development and underlies its aggressiveness, yet its role in tumor‐immune interactions remains poorly understood. Here, we investigate how p53 loss alters osteosarcoma susceptibility to natural killer (NK) cell‐mediated cytotoxicity using OS cell lines and...
Gui-Hui Qin, Cheung-Kwan Yeung, Ye Yi et al.
· Advancement of science · 0 citations