Author

Chuting Xu

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Open access Jul 2026

Targeted degradation of hepatic KEAP1 mitigates drug-induced liver injury via dual boosting NRF2 and PGAM5 signaling

A liver-preferential KEAP1 degrader was developed to mitigate DILI by dual activation of the NRF2 and PGAM5 pathways, offering a promising therapeutic agent and more in-depth mechanistic insights into KEAP1-targeted degradation for enhanced anti-DILI therapy.

Yanyan Deng, Leizhi Xu, Xiaoting Niu et al. · Redox Biology · 0 citations

Aug 2026

Astragalus polysaccharides ameliorate irinotecan-induced gut toxicity by regulating gut microbiota and suppressing the MAPK signaling.

Findings suggest that APS, the key active fraction of AM against IGT, mitigate IGT by modulating microbiota-metabolite-MAPK axis, offering novel mechanistic insight for the ethnopharmacological use of AM to mitigate chemotherapy-induced intestinal toxicity.

Bolin Wu, Chenyang Zhou, Chu-Ting Xu et al. · Journal of Ethnopharmacology · 0 citations