Author

Chrystal M. Paulos

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Sep 2026

Abstract B085: Development of a Translational Manufacturing Strategy for a Novel CD4+ CD26+ mesoCAR T Cell Product for Pancreatic Ductal Adenocarcinoma Patients

The emergence of KRAS inhibitors is reshaping the therapeutic landscape of pancreatic ductal adenocarcinoma (PDAC). Yet responses are seldom durable, and relapse is inevitable, highlighting the ongoing need for aggressive therapeutic strategies. PDAC also remains unresponsive to adoptive T cell therapies (ACT), highl...

D. Evans, Megan M. Wyatt, Anna C. Cole et al. · Cancer Research · 0 citations

Sep 2026

Abstract B086: Mesothelin-targeted CAR Th1/17 cells are a novel cellular engineering platform for pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) remains refractory to immunotherapies, including adoptive T cell therapy, necessitating evaluation of alternative T cell engineering platforms in immunosuppressive solid tumors. Human CD4+ T cells co-secreting IFN-γ and IL-17A (Th1/17 hybrids) have demonstrated enhanced ant...

Delaney K. Geitgey, Megan M. Wyatt, Maggie J. Phillips et al. · Cancer Research · 0 citations

Jul 2026

PI3K Delta Inhibition Alters CD8 T Cell Différentiation and Reprograms the Tumor Microenvironment Following Adoptive Immunotherapy 2247548

PI3Kδ inhibition programs T cells with stemness and metabolic fitness that favor Tpex differentiation, resist terminal exhaustion, and remodel the TME toward an inflammatory state, supporting a practical strategy to improve ACT efficacy in solid tumors.

Alexandrea Turnquist, Azka Javaid, F. Kolling et al. · Journal of Immunology · 0 citations