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Author

Christos Spanos

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2 papers indexed here

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Open access Sep 2026

Meiotic kinetochore reconstitution identifies chromosome segregation factors

Kinetochores are complex protein assemblies at centromeres that direct and regulate chromosome segregation1. During gamete formation by meiosis, kinetochore specialisations drive two sequential and distinct segregation events to partition half the genome to the offspring2,3. Age-dependent segregation errors in human oo...

G. Pieper, Niamh O'Loughlin, M. Aboelenain et al. · 0 citations
Open access Aug 2026

HECT-type ligases facilitate autoubiquitination and degradation of other ubiquitin ligases to activate plant immunity

The discoveries suggest that during plant immunity, HECT-type ligases and the proteasomes they associate with, control cellular proteostasis by governing the stabilities of both E3 ligases and their substrates by controlling the stability of autoubiquitinating E3 ligases.

Zhi-Shuo Wang, Robert O. Mason, Heather Grey et al. · 0 citations

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