Open access
Aug 2026
Discovery and evolution of an (R)-selective transaminase for production of sitagliptin
R reverse screening as an effective approach for evolving transaminases toward sterically hindered substrates is validates reverse screening as an effective approach for evolving transaminases toward sterically hindered substrates and highlights RTA-223 as a promising candidate for further biocatalyst development.
Matthew Treadell, Gareth R E Surman, G. Ford et al.
· RSC Chemical Biology · 0 citations