Author

Christopher J. Petzold

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Open access Oct 2026

Orchestrating polyketide synthase-derived aldehyde metabolism for Streptomyces biomanufacturing.

Advances in metabolic engineering have enabled the integration of diverse non-native reactions into microbial hosts, providing sustainable alternatives to petrochemical manufacturing. We previously developed a modular polyketide synthase (PKS)-based platform in Streptomyces albus for producing 17 diols, amino alcohols,...

Q. Dan, Xi-Na Wang, Yan Chiu et al. · Metabolic Engineering · 0 citations

Open access Jul 2026

Simultaneous optimization of lignocellulosic sugar catabolism via systematic laboratory evolution under complex selection pressure

Efficient co-utilization of hexose and pentose sugars from lignocellulose is essential for microbial bioconversion, yet engineered catabolic pathways can be unstable or suboptimal in complex resource environments. Here, we use a Pseudomonas putida strain engineered to catabolize xylose and arabinose to examine how reso...

Sunghwa Woo, H. Lim, B. Norton-Baker et al. · Nature Communications · 0 citations