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Author

Christopher E. Nelson

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Open access Oct 2026

A Hypertrophic Stimulus Drives Age‐Dependent Transcript Isoform Switching With and Without Differential Gene Expression in Skeletal Muscle

Aged skeletal muscle has a reduced ability to adapt to hypertrophic stimuli concomitant with dysregulation across several molecular layers. Whether altered RNA splicing associates with impaired adaptive potential is not well studied. We hypothesized that aging disrupts the splicing response to involuntary muscle mechan...

Pieter J. Koopmans, Abbey L. Stokes, Christopher E. Nelson et al. · 0 citations

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