Open access
Oct 2026
Modulator Resolves Transcript-, Allele-, and Condition-associated RNA Modification Differences from Direct RNA Sequencing
Nanopore direct-RNA sequencing (DRS) reports RNA modifications on single molecules, but there is no comprehensive algorithm for processing, aligning, and differentiating base modifications across reads that are often 5′-truncated. Here we present Modulator, which assigns every read, truncated or not, to a “fragmentform...
Theodore M. Nelson, Michael Goneos, Caroline J. Aufgebauer et al.
· bioRxiv · 0 citations