Author

Christoph Kuppe

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Open access Aug 2026

Cell-type-specific damage scores reveal kidney and liver disease trajectories in single-cell and spatial transcriptomics.

Degenerative diseases progress through gradual cell-intrinsic damage that is difficult to resolve with bulk transcriptomics or discrete cell-state analysis. We introduce a generalizable single-cell and spatial transcriptomics framework that quantifies continuous damage trajectories in vivo using cell-type-specific scor...

Tsimafei Padvitski, Paula Unger Avila, He Chen et al. · Cell Genomics · 1 citation

Open access Sep 2026

Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment.

This work supports the goal of dual-purpose clinical trial designs that integrate aging endpoints into studies for specific disease indications by identifying potential anti-aging shifts in senescence and metabolic processes alongside the anti-fibrotic activity of rentosertib.

Alex Zhavoronkov, F. Galkin, Shan Chen et al. · Nature Biotechnology · 1 citation

Open access Aug 2026

Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering

This work presents SACCELERATOR, an open-source, extensible framework that formalizes expert-guided spatial clustering analysis, and proposes a consensus-guided workflow where descriptive spatial metrics highlight high-entropy regions of method disagreement, enabling targeted feedback for tissue experts.

Jieran Sun, Kirti Biharie, Peiying Cai et al. · Nature Methods · 0 citations