Cysteine-Based Amino Acid Mimetics as First-in-Class Antitubercular Agents: Discovery, SAR, and Identification of a Lead Compound with Intracellular Activity
Tuberculosis (TB), caused byMycobacterium tuberculosis (Mtb), remains a leading global infectious disease killer, and the emergence of drug-resistant strains underscores the urgent need for new antitubercular agents with novel mechanisms of action. Herein, we report the discovery of cysteine-based amino acid mimetics...