Christin Findeisen

The risk of nephrotic range proteinuria and kidney failure in primary laminopathies is genotype specific

While patients with Lamin A/C Arg482 missense changes are at very low risk for progressive CKD, patients harboring Arg349Trp show nephrotic range proteinuria and kidney failure in midlife, and patients with the Arg349Trp substitution require early renoprotective intervention to potentially halt progression and prevent...