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Christiane Carter

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Open access Oct 2026

Hepatocyte Serine Palmitoyltransferase 3 is essential for mitochondrial ceramide homeostasis and electron transport chain function.

Sphingolipids constitute essential membrane lipids that also function as signaling molecules mediating fundamental cellular processes. Disruption of constitutive sphingolipid metabolism contributes to a range of metabolic diseases. Sphingolipid biosynthesis is initiated by serine palmitoyltransferase (SPT), a heteromer...

Maryam Jamil, Anna Kovilakath, Yolander A. Valentine et al. · 0 citations
Open access Aug 2026

Sphingosine kinase 2 regulates adipocyte browning and whole-body metabolism

Obesity increases circulating levels of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). Here, we identify adipocyte-expressed sphingosine kinase 2 (SPHK2), an enzyme that produces S1P, as a regulator of adipose tissue browning. Mice with adipocyte-specific deletion of Sphk2 were protected from West...

R. Brown, Cynthia Weigel, Yadu Vijayan et al. · 0 citations

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