Christian Wechselberger

Particulate matter selectively promotes macropinocytosis and malignant transformation-associated phenotypes in p53-impaired epithelial cells.

Fine particulate matter (PM2.5; aerodynamic diameter <2.5µm) is associated with respiratory and cardiovascular disease and is classified, together with outdoor air pollution, as carcinogenic to humans. However, mechanisms underlying its tumor-promoting effects remain incompletely defined. We examined acute and repeated...