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Author

Christian Lesterlin

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Open access Oct 2026

Antibiotic inhibition uncouples growth from horizontal gene transfer

Conjugative plasmids often encode resistance to multiple antibiotics, allowing a single mobile genetic element to transfer across diverse selective environments. This co-selection is often invoked to explain the persistence and spread of multidrug resistance, with antibiotic resistance genes encoded on the same plasmid...

Heather D. Curtsinger, G. Quintero, Aidan Larish et al. · 0 citations
Open access Sep 2026

Model-based evaluation of Targeted-Antibacterial-Plasmids (TAPs) transfer kinetics and resensitization of pOXA-48 carbapenem-resistant Escherichia coli

Background Targeted-Antibacterial Plasmids (TAPs) are engineered mobile genetic elements that use bacterial conjugation to deliver selective CRISPR/Cas9 antibacterial activity against a specific target strain. Yet, the efficiency of TAPs is typically evaluated at a single time point, whereas the success of TAP-mediated...

S. Marolleau, J. Moreau, J. Buyck et al. · 0 citations
Open access Jul 2026

Widespread immune systems protect bacteria against conjugative plasmids

A large-scale analysis of 364 diverse strains of the opportunistic pathogen Acinetobacter baumannii as recipients of the broad-host-range conjugative plasmids R388 and RP4 reveals an additional layer of bacterial immunity directed at a class of genetic elements driving dissemination of antibiotic resistance.

L. Poiré, J. Baltenneck, Salomé Guillory et al. · 0 citations

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