Christian Gille

Gut-derived small extracellular vesicles support trained innate immune tolerance in murine microglial cells

Introduction Microglia are the resident immune cells of the central nervous system (CNS) that maintain tissue homeostasis and contribute to the pathogenesis of neuroinflammatory disorders. As innate immune cells, microglia can acquire memory-like states that exert long-term effects on CNS function and disease susceptib...