Open access
Sep 2026
Novel 3D models for β-catenin-driven liver cancers.
BACKGROUND & AIMS Constitutive activation of β-catenin is a key feature in the pathogenesis of HCC and hepatoblastoma (HB). Activating alterations in the CTNNB1 gene and, to a lesser extent, inactivating alterations in the APC gene are observed in 30-40% of HCC cases and 80-90% of HB cases. For both tumours, therapeuti...
Vanessa Bou Malham, Fanny Léandre, Akila Hamimi et al.
· JHEP Reports · 0 citations