Open access
Jul 2026
Co-delivery of lentiviral vectors and Cas9-containing virus-like particles enables rapid, scalable manufacture of gene-edited CAR T cells
Chimeric antigen receptor T cell immunotherapies are transforming therapies for hematological malignancies and solid tumors and can be enhanced by targeted gene knockout. Here, we report lentiviral-based virus-like particles that package and deliver Cas9 ribonucleoproteins to primary human T cells. Using distinct pseud...
Francesca Ferrara, Matthew M Wielgosz, Jeoungeun J. Park et al.
· Molecular therapy. Advances · 0 citations