Dual-functional bacterial extracellular vesicles with therapeutic oligonucleotides for synergistic treatment of ischemia/reperfusion injury in the brain.
INTRODUCTION Ischemia/reperfusion (I/R) injury refers to secondary damage that occurs following ischemic stroke when reperfusion is achieved using thrombolytic agents. The abrupt restoration of blood flow induces excessive production of reactive oxygen species (ROS), inflammatory cytokines, and infiltration of immune c...