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Chor Lai Lam

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Open access Aug 2026

α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease

The primary mechanism and subcellular localisation of α-synuclein toxicity in Parkinson’s disease pathogenesis remain unknown. We spatially and temporally resolved proteomic and transcriptomic changes in human iPSC-derived dopaminergic neurons with increasing burden of pathological α-synuclein. We found that misfolded...

Chor Lai Lam, N. Gatford, Ana Aragón-González et al. · 0 citations

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