Chong Chu

The Role of Germline Transposable Element Insertions in Pediatric Cancer Predisposition

Abstract At least 10 to 15% of children with cancer have a pathogenic germline variant in a cancer predisposition gene. Studies of germline cancer predisposition, however, have focused primarily on single-nucleotide and copy-number variants, leaving other classes such as transposable elements (TE) largely unexplored. A...