Leveraging Scalable Non-Mammalian Systems for Large-Scale Studies of Autism Risk Gene Function.
There are over 100 large-effect genes strongly associated with autism spectrum disorder (ASD), yet advancing from risk genes to the discovery of common biological pathways and pharmacological targets remains a central challenge. Scalable non-mammalian systems, including Caenorhabditis elegans (roundworm), Drosophila me...