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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Ching-Wen Chang

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Open access Oct 2026

A Novel Chemotype of Orally Active SARS-CoV-2 NSP14 Methyltransferase Inhibitors

The periodic emergence of human coronaviruses (hCoVs) necessitates direct-acting antivirals targeting underexploited viral proteins with broad-spectrum potential. Building on our discovery of TDI-015051, a first-in-class SARS-CoV-2 mRNA cap guanine-N7 methyltransferase (MTase) NSP14 inhibitor whose translational deve...

Cindy Meyer, Aitor Garzia, J. R. Merritt et al. · 0 citations
Open access Aug 2026

Coronavirus NSP14 drives internal m7G modification to rewire host splicing and promote viral replication

Using SARS-CoV-2 infection models, it is shown that viral replication is associated with increased cellular m7G signal, supporting the relevance of this pathway during infection and suggesting that NSP14-induced m7G modification may contribute to the remodeling of host gene expression during coronavirus infection.

Ensueño Esmeralda Sáenz Altamirano, Chien-Hsin Huang, Yueh-Lin Tsai et al. · 0 citations

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