Author

Chih-chi Andrew Hu

3 papers indexed here

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Open access Sep 2026

Endothelial PERK restricts lymphoid regeneration by reducing DLL4-NOTCH3 signaling at the Pre-B niche.

Delayed immune recovery after hematopoietic stem cell (HSC) transplantation is associated with a poor clinical outcome. We study the role of unfolded protein response (ER stress) in hematopoietic regeneration within the bone marrow (BM) microenvironment. We reveal that BM endothelium PERK activation is a prominent feat...

Bing-Qing Zou, Qiu-Yun Chen, Jun-Jun Zheng et al. · Cell Reports · 0 citations

Open access Oct 2026

Chronic XBP1s-mediated activation of the unfolded protein response impairs CD8+ T cell anti-tumor immunity

CD8 + T cells play a crucial role in anti-tumor immunity; however, their functionality is compromised by exhaustion driven by chronic antigen exposure, poor tumor microenvironment, and metabolic dysfunction. Activated CD8 + T cells undergo extensive proteomic remodeling, which includes the induction of the IRE1-X...

Keith A. Nair, Jessica Lee, Olivia Zaleski et al. · Frontiers in Immunology · 0 citations

Open access Sep 2026

IRE1α-XBP1s signaling links lipid homeostasis to hypoxic maladaptation and KRAS inhibitor responses in pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is among the most hypoxic human tumors. Because fatty acid (FA) desaturation is oxygen-dependent, hypoxia can limit monounsaturated FA (MUFA) production, increase membrane lipid saturation, and activate endoplasmic reticulum stress responses, including IRE1α-XBP1s. Here, we found...

Yan-Qing Jiang, Cassidy Pagen, Gusangyu Yin et al. · Proceedings of the National... · 0 citations