Open access
Oct 2026
Human macrophages activate a coordinated program linking inflammation and cell death in response to intracellular Poly(I:C)
Macrophages sense viral double-stranded RNA (dsRNA) via the innate immune receptors TLR3 and MDA5 whose activation drives a robust inflammatory program, often coupled to cell death. TLR3/TRIF-dependent apoptosis has been described in response to dsRNA. Growing evidence suggests that dsRNA may trigger multiple forms...
Luigi Fiore, Lara Di Leonardo, M. Buscetta et al.
· Frontiers in Immunology · 0 citations