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Author

Chenqi Niu

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Oct 2026

A precursor-driven triterpenoid platform enables high-level biosynthesis of structurally distinct triterpenoids in Saccharomyces cerevisiae.

A precursor-driven strategy utilizing post-translational ubiquitin-based N-degrons was developed to dynamically attenuate Erg7p stability, offering a scalable template for sustainable industrial biomanufacturing of complex natural products.

Jing-Tao Zhou, Hai-Lang Ma, Chang-Wen Ye et al. · 0 citations
Aug 2026

Mechanistic Decoupling of the cis - and trans -Cleavage Activities of Cas12a via Phosphorothioate-Induced Kinetic Trapping

It is demonstrated that the availability of the RuvC catalytic channel is determined not by induced fit binding but by the chemical cleavability of the occupant, which provides a theoretical framework and additional insights for developing more precise gene-editing tools and designing Cas12a-based in vitro diagnostic p...

Chenqi Niu, Yiyi Mi, Wanxia Zhao et al. · 0 citations

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