Anthraquinone-fused enediynes (AFEs) are a class of microbial natural products with remarkable cytotoxicity and exhibit promising application prospects in tumor therapy. Taking tiancimycins (TNMs) as an example, this class of compounds holds great potential against triple-negative breast and liver cancers. However, the...
Drug development has long been constrained by high costs, lengthy timelines, and low success rates, primarily due to the insufficient human physiological fidelity of traditional preclinical models. Artificial intelligence (AI) has accelerated computational drug discovery, but its models inherit training-data bias and a...
Qian Yong, Chun-Yang Chen, Xi-Meng Zhang et al.· International journal of pha...· 2 citations
A multifunctional peptide-based antibacterial hydrogel (PAHG) for treating infected wounds, constructed through the incorporation of Cys-Arg-NH2 (CR)-Ag nanoassemblies into a bioactive matrix with excellent antibacterial activity against Escherichia coli and methicillin-resistant Staphylococcus aureus.
Heng Ge, Wen Yuan, Yulin Sun et al.· Journal of materials chemist...· 0 citations
It is demonstrated that the catechol-nanocellulose/chitosan polymeric hydrogel effectively overcomes adhesion, infection, and oxidative stress barriers in diabetic wound healing, making it a promising candidate for difficult-to-heal chronic ulcers.
