Development of pH-responsive ZIF-8-based multimetallic redox nanoreactors for ferroptosis-mediated cancer therapy.
A structurally reinforced ternary redox-cycling nanoreactor that integrates Zr4⁺-stabilized zeolitic imidazolate framework-8 with redox-active Cu/Mn centers and ultrasmall Au nanodots achieves sustained ROS amplification, iron-homeostasis remodeling, and enhanced tumor-selective ferroptosis, offering a promising therapeutic strategy for TNBC.