Author

Chengdong Chang

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Open access Aug 2026

NF-κB/Lipocalin 2 Signaling Pathway Mitigates the Chemoresistance of BRAFV600E-Mutant Colorectal Cancer to Cisplatin by Promoting Ferroptosis

A key role is found for NF-κB/Lipocalin 2 (LCN2)-signaling-pathway-induced ferroptosis in modulating cisplatin sensitivity of V600E-overexpressing CRC cells to cisplatin within a KRAS-mutant cellular background, implying LCN2 as a potential therapeutic target.

M. Feng, Xuesong Wu, Li Jiang et al. · Cancers · 0 citations