Author

Cheng-Ying Chu

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Open access Oct 2026

Optimisation and mechanistic characterization of a selective benzoxazine-based MAP4K4 inhibitor in pancreatic cancer cells

Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with limited targeted therapeutic options. Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) has been implicated in PDAC progression, but the development of effective MAP4K4 inhibitors requires further improvement in potency, se...

Yi-Wen Wu, Chun-Lin Yang, Yu-Ting Fang-Chin et al. · Journal of Enzyme Inhibition... · 0 citations

Open access Sep 2026

Thioredoxin reductase-1 facilitates cellular plasticity and stemness mediated by TGF-β1 in non-small cell lung cancer

This study identifies TXNRD1 as a crucial regulator of cellular plasticity and metastasis in NSCLC via the TGF-β1 pathway, suggesting that targeting TXNRD1 may reduce metastatic potential and improve patient survival.

Yaw-Dong Lang, Shin-Yuan Gu, Jou-Ho Shih et al. · Cancer Biology & Therapy · 0 citations