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Cheng-Yi Zhang

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Review Open access Oct 2026

CAR-T cell therapy for solid tumors: antigen landscape, biological barriers, and engineering strategies for clinical translation

Chimeric Antigen Receptor T (CAR-T) cell therapy has emerged as a promising therapeutic option, particularly for refractory and relapsed leukemias. However, its efficacy in treating solid tumors, including lung, ovarian, gastric, and breast cancers, remains limited by several challenges. Recent studies have highlighted...

Qian Niu, Meng Li, Cheng-Yi Zhang et al. · 0 citations

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