Mechanism of Isonitrilase, a Nonheme Iron Decarboxylase Involved in the Biosynthesis of the Isonitrile Group in Peptides: A Computational Study.
Surprisingly, there are quite a few natural products that contain an isonitrile substituent as these groups enhance the activity and function of the natural product. Various enzymes in nature are involved in the biosynthesis of an isonitrile group in biomolecules. Thus, the mycobacterial Rv0097 isonitrilase reacts the...