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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Chengjie Zhou

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Open access Aug 2026

Subcellularly Resolved 3D Translatome in Mouse Oocytes and Early Embryos

Spatial patterning of mRNA translation is a fundamental process in early embryogenesis. Existing RNA translation profiling methods lack subcellular spatial resolution at the single-molecule level, limiting our understanding of spatial RNA biology in embryogenesis. To address this, we profiled the spatial translatome of...

Jingyi Ren, Seth Furniss, Cheng-Jie Zhou et al. · 0 citations
Open access Sep 2026

Hierarchical chromatin polyvalency governs robust gene regulation and organogenesis

Precise temporal control of gene expression is fundamental for embryonic development, yet the epigenetic and chromatin basis governing transcriptional timing remain poorly understood. The bivalency model, characterized by coexistence of H3K4me3 and H3K27me3, has been proposed to mark a poised state ready for activation...

Cheng-Jie Zhou, Meng Wang, Zhi-Yuan Chen et al. · 0 citations
Open access Aug 2026

Rescue schizophrenia-related phenotypes caused by Setd1a deficiency by histone demethylase inhibitors

This work provides a mechanistic link between high-penetrance SETD1A variants and region-specific brain dysfunction, establishing a framework for connecting rare loss-of-function variation in chromatin regulators to multidimensional neuropsychiatric phenotypes.

Yiqiong Liu, Guoguang Xie, Shan Jiang et al. · 0 citations

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