Cheng-Jian Wu

Ketone body metabolism is associated with macrophage heterogeneity and a protumor phenotype in gastric cancer through single cell and bulk transcriptomic analysis

The tumor microenvironment (TME) in gastric cancer (GC) is characterized by significant heterogeneity, particularly among tumor-associated macrophages (TAMs). While metabolic reprogramming is a hallmark of cancer, the role of ketone body metabolism in shaping macrophage heterogeneity and its functional impact in...