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Cheng-Hua Xu

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Open access Sep 2026

XY0206 targets FLT3-dependent resistance states in acute myeloid leukemia.

Activating mutations in FMS-like tyrosine kinase 3 (FLT3) drive aggressive acute myeloid leukemia (AML) and confer poor prognosis. Although FLT3 inhibitors have improved outcomes, their efficacy is frequently limited by microenvironment-mediated signaling and treatment-emergent resistance. XY0206 is a structurally opti...

Long Shen, Yang Yang, Cheng-Hua Xu et al. · 0 citations

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