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Chen Zhao

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#machine learning Preprint Oct 2026

ColdDDI: Evaluating Knowledge Utilization in Cold-Start Drug-Drug Interaction Prediction

Cold-start drug-drug interaction (DDI) prediction tests whether models can identify clinically significant interactions for drugs without training-time interaction history. Existing benchmarks mostly report aggregate edge-prediction scores, leaving a key evaluation question unanswered: when models receive molecular, te...

Ji-Heng Liang, Chen Zhao, Di Wu et al. · 0 citations
Book Open access Aug 2026

AI for Precision Medicine: Histopathology-centered Computational Analysis of Spatial Omics: Integration, Mapping, and Foundation Models

Spatial omics (SO) technologies enable spatially resolved molecular profiling, while hematoxylin and eosin (H&E) imaging remains the gold standard for morphological assessment in clinical pathology. Recent computational advances increasingly place H&E images at the center of SO analysis, bridging morphology with transc...

Ning-Hui Hao, Bo-Shen Yan, Dong Li et al. · 0 citations
Book Open access Aug 2026

AI for Precision Medicine: Histopathology-centered Computational Analysis of Spatial Omics: Integration, Mapping, and Foundation Models

This lecture-style tutorial surveys the algorithmic foundations and recent advances in method development that make them practical and impactful for precision medicine, and outlines opportunities for the KDD community to contribute principled data mining and learning approaches to multimodal spatial biology.

Ninghui Hao, Boshen Yan, Dong Li et al. · 0 citations

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