Ginkgolide A alleviated liver fibrosis by modulating PI3K/AKT/NF-κB signaling to inhibit M1 macrophage polarization and macrophage-HSC crosstalk.
Liver fibrosis (LF) is a progressive pathological process driven by chronic hepatocyte injury and aberrant wound healing, culminating in excessive extracellular matrix (ECM) deposition primarily mediated by activated hepatic stellate cells (HSCs). A dysregulated hepatic immune microenvironment, orchestrated in large pa...