Open access
Jul 2026
The human LRRK2-R1441G mutation drives age-dependent oxidative stress and mitochondrial dysfunction in dopaminergic neurons.
Findings reveal an age-dependent progression of mitochondrial dysfunction in BAC-hR1441G SNc DA neurons, and dysregulation of calcium channels and uncoupling proteins emerges as a key mechanism contributing to bioenergetic failure, suggesting potential therapeutic targets to mitigate PD progression.
Yuanxin Chen, Lianteng Zhi, Shiquan Cui et al.
· Molecular Neurodegeneration · 1 citation