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Chen-Yuan Jiang

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Sep 2026

Hsc70-Mediated Targeting Chimeras for Targeted Protein Degradation via Chaperone-Mediated Autophagy

Despite the remarkable success of proteolysis-targeting chimeras (PROTACs), challenges such as limited applicability to certain cytosolic proteins, potential resistance risks, and off-target effects remain. Novel degradation strategies harnessing the autophagy/lysosome pathway may broaden the scope of protein targets...

Chao Chen, Yi-Lun Zheng, Xiu-Yu Tao et al. · 0 citations

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