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Open access Jul 2026

KLF2 regulates CD8 T cell differentiation and migration in infection and cancer 2254075

Besides acute infection, CX3CR1+ effector-like CD8 T cells also appear in chronic infection and cancer. Whether there is a central transcriptional regulator of the effector fate is unclear. Here, using joint single-cell profiling of the transcriptome and epigenome of chimeric antigen receptor (CAR) T cells...

Tuoqi Wu, Ziang Zhu, Ying Luo et al. · 0 citations
Open access Jul 2026

BACH2 dosage establishes the hierarchy of stemness and finetunes antitumor immunity in CAR T cells 2256626

Self-renewing stem-like T cells promote the efficacy of cancer immunotherapy and are a heterogeneous population with sub-lineages demonstrating different degrees of stemness. At the apex of this hierarchy are long-term (LT) stem-like T cells with the highest capacity of persistence, repopulation and response to i...

Chen Yao · 0 citations

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