Construction of a dual-compartment hydrogel by protein-based triblock copolymer for the in situ delivery of volatile bioactives in inflamed environments
Naturally occurring volatile bioactives, such as allyl isothiocyanate (AITC), represents a class of potent antimicrobial candidates, yet their clinical translation is severely hindered by inherent volatility and mucosal irritation. On the other hand, the prevalent extracellular acidification characteristic of inflammat...