Discriminating Monomers and Fibrils of Amyloid-β1-42 With Site-Ordered Peptide-QMFluors.
The detection of soluble amyloid-β (Aβ), the most neurotoxic species in early Alzheimer's disease (AD), remains a major analytical challenge. Conventional probes are designed to target the β-sheet structures of mature fibrils and are thus blind to these transient, nonfibrillar species. Here, we introduce "site-ordered...