Author

Chen Xu

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Open access Sep 2026

Sodium butyrate ameliorates intestinal motility and is associated with enteric neuroimmune changes in slow transit constipation mice

Background The pathogenesis of slow transit constipation (STC) is still not fully elucidated, and there are no related specific drugs currently available for clinical use. Therefore, our study combined 16S ribosomal RNA (rRNA) gene sequencing, untargeted metabolomics, transcriptomic analysis, and a mouse intervention m...

Bing-Bing Ren, Si-Qi Fu, Xiang-Ying Wang et al. · Frontiers in Immunology · 0 citations

Open access Oct 2026

Mendelian randomization of gut microbiota and exploratory testing of preventive effect of commercial Rothia mucilaginosa in constipated mice

Constipation is linked to gut microbiota dysbiosis, but causal microbial contributors and tractable bacterial interventions remain incompletely defined. This study first performed two-sample Mendelian randomization using Dutch Microbiome Project gut-microbiome Genome-Wide Association Study (GWAS) data ( N  = 7,738)...

P. Jiang, Xiao-Qing Yang, Cheng-Hao Zhang et al. · Frontiers in Microbiology · 0 citations