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Author

Chenxi Wang

2 papers indexed here

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Sep 2026

Discovery of a Potent, Selective, and Orally Efficacious STAT6 PROTAC for the Treatment of Atopic Dermatitis

Signal transducer and activator of transcription 6 (STAT6), a key mediator of IL-4/IL-13 signaling, regulates Th2 differentiation, making it an attractive target for atopic dermatitis (AD). The reported phosphopeptide-based STAT6 proteolysis-targeting chimera (PROTAC) established proof of concept for targeted STAT6 d...

Wen-Tao Wang, Meng-Yu Zhao, Liu-Zhi Hu et al. · 0 citations
Open access Aug 2026

Mut-p53 acts as a synthetic lethal partner with E2F3 inhibition in gastric cancer under FGFR1 inhibitor.

This study demonstrates that FGFR1 inhibition induces synthetic lethality in mutant p53 gastric cancer by targeting the E2F3 axis, and suggests that S29 provides a strategic therapeutic approach for patients with TP53 mutations.

Si-Jia Zhong, Fanxi Meng, Leyu Wan et al. · 0 citations

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